The
RU 486 or mifepristone or Mifégyne®, was born in France in 1980. Known
then "abortion pill", she had led an outcry movements opposed to
abortion. Previously reserved for the hospital, she has since July 28, 2004, available in some gynecologists and general practitioners.
The Mifégyne® has a molecular structure very similar to that of the steroid hormones and binds with high affinity to the progesterone receptor. She then a true anti-progesterone effect and acts in particular on the gravid uterus resulting in a softening of the cervix, an increase in the contractility of the uterine muscle and promotes the detachment of the embryo.
RU 486 abortion and
The medical abortion can be performed in medicine today "city". Nevertheless, this act should be performed under the supervision of a gynecologist or a general practitioner working in a network with a health facility with which he spent convention. This method can not be used beyond 7 weeks of no rules. Specifically, women will pay an initial consultation with his doctor who will inform the different techniques and propose him a psycho-social care. At a second meeting, she will sign a consent and then during the third consultation, tablet Mifégyne® (Mifepristone) will be administered. 48 hours later, the woman should take Misoprostol. You should know that interrupts pregnancy Mifepristone and Misoprostol causes the evacuation of the egg, as in a miscarriage. Finally a check-up is required from 15 to 20 days later. If this method is effective in 98% of cases, in 2% of cases, pregnancy can continue. So it is imperative to see your doctor to ensure no complications.
RU 486 and therapeutic abortions
The Mifégyne® has profoundly altered the achievement of therapeutic abortions (ITG). The RU486 makes it possible to prepare the cervix and uterine muscle to the action of prostaglandins that are used to get contractions and cause expulsion of malformed fetus. Practically Mifégyne® tablets are taken two days before hospitalization scheduled for termination of pregnancy. This will significantly reduce the doses of prostaglandins necessary for expulsion.
In case of intrauterine death
When the fetus dies spontaneously (fetal death in utero), pregnancy does not necessarily end immediately and it is often necessary to speed up the work and the expulsion of the fetus, especially in order to avoid infections. Taking tablets Mifégyne® is then indicated to facilitate the action of prostaglandins. Often, under these conditions, the RU 486 is sufficient to induce labor.
The lines of research
Several studies are underway to validate or evaluate the effectiveness of RU 486 in other indications:
Preparation of the cervix and trigger the forward work on living fetus;
Emergency Contraception: Taking the RU 486 could be delayed up to 120 hours after intercourse potentially fertilizing while offering 85% efficiency and very good tolerance;
In combination with methotrexate, RU 486 is used experimentally for the medical treatment of ectopic pregnancy (GEU);
Medical treatment of certain tumors: breast, mé ningiome, leiomyoma.
The Mifégyne® has a molecular structure very similar to that of the steroid hormones and binds with high affinity to the progesterone receptor. She then a true anti-progesterone effect and acts in particular on the gravid uterus resulting in a softening of the cervix, an increase in the contractility of the uterine muscle and promotes the detachment of the embryo.
RU 486 abortion and
The medical abortion can be performed in medicine today "city". Nevertheless, this act should be performed under the supervision of a gynecologist or a general practitioner working in a network with a health facility with which he spent convention. This method can not be used beyond 7 weeks of no rules. Specifically, women will pay an initial consultation with his doctor who will inform the different techniques and propose him a psycho-social care. At a second meeting, she will sign a consent and then during the third consultation, tablet Mifégyne® (Mifepristone) will be administered. 48 hours later, the woman should take Misoprostol. You should know that interrupts pregnancy Mifepristone and Misoprostol causes the evacuation of the egg, as in a miscarriage. Finally a check-up is required from 15 to 20 days later. If this method is effective in 98% of cases, in 2% of cases, pregnancy can continue. So it is imperative to see your doctor to ensure no complications.
RU 486 and therapeutic abortions
The Mifégyne® has profoundly altered the achievement of therapeutic abortions (ITG). The RU486 makes it possible to prepare the cervix and uterine muscle to the action of prostaglandins that are used to get contractions and cause expulsion of malformed fetus. Practically Mifégyne® tablets are taken two days before hospitalization scheduled for termination of pregnancy. This will significantly reduce the doses of prostaglandins necessary for expulsion.
In case of intrauterine death
When the fetus dies spontaneously (fetal death in utero), pregnancy does not necessarily end immediately and it is often necessary to speed up the work and the expulsion of the fetus, especially in order to avoid infections. Taking tablets Mifégyne® is then indicated to facilitate the action of prostaglandins. Often, under these conditions, the RU 486 is sufficient to induce labor.
The lines of research
Several studies are underway to validate or evaluate the effectiveness of RU 486 in other indications:
Preparation of the cervix and trigger the forward work on living fetus;
Emergency Contraception: Taking the RU 486 could be delayed up to 120 hours after intercourse potentially fertilizing while offering 85% efficiency and very good tolerance;
In combination with methotrexate, RU 486 is used experimentally for the medical treatment of ectopic pregnancy (GEU);
Medical treatment of certain tumors: breast, mé ningiome, leiomyoma.
0 commentaires:
Enregistrer un commentaire